Stop spead swine flu docxtor advice salt swab gargle

Due to limited treatment options for COVID-19, preventive measures play a major role in controlling the disease spread.

Even though remdesivir, hydroxychloroquine and lopinavir-ritonavir combination has been tested clinically, many trials suggest that these drugs are not completely effective for the treatment of COVID-19 7. To date, there is no effective specific antiviral for SARS-CoV-2. Virus transmission through asymptomatic patients is a major challenge to disease containment. Moreover, more than half of the infected patients were young and asymptomatic 6. The COVID-19 is difficult to contain due to high transmissibility rate and a long incubation period of 5 to 14В days 5. The virus replicates in the nose and throat, as evidenced by the high viral load at the early stage of infection, at the beginning of symptoms 4. The pathogenesis begins when SARS-CoV-2 attacks the nasal cavity, nasopharynx, oropharynx and eye mucus membranes. The virus spreads via respiratory droplets when infected individuals sneeze or cough or indirectly through objects contaminated with respiratory droplets. SARS-CoV-2 is an envelope, non-segmented, positive sense RNA virus identified as a novel beta coronavirus after SARS-CoV and MERS-CoV 3. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been implicated as the causative agent of COVID-19 based on genetic analysis of the virus from the first few cases detected in Wuhan, China 2. Since its first discovery in December 2019, coronavirus disease 2019 (COVID-19) has affected more than 200 million people and caused more than 4 million deaths worldwide 1. Gargle formulations with cetylperidinium chloride, chlorhexidine and hexetidine have great potential in reducing SAR-CoV-2 at the source of entry into the body, thus minimizing risk of transmission of COVID-19.

In addition, salt water was not proven effective. Thymol formulations achieved only 0.5 log 10 reduction in viral titres.

Formulations with cetylperidinium chloride, chlorhexidine and hexitidine achievedвЂ‰>вЂ‰4 log10 reduction in viral titres when exposed within 30В s under both clean and dirty conditions. A reduction in virus titer of 4 log 10 corresponds to an inactivation ofвЂ‰в‰ҐвЂ‰99.99%. Virus titres were calculated as 50% tissue culture infectious dose (TCID50/mL) using the Spearman-Karber method. The cytotoxicity of the products to the Vero E6 was evaluated by kill time assay based on the European Standard EN14476:2013/FprA1:2015 protocol. The virus was isolated and propagated in Vero E6 cells. Four commercially available mouthwash/gargle formulations were tested for virucidal activity against SARS-CoV-2 in both clean (0.3В g/l BSA) and dirty (0.3В g/l BSAвЂ‰+вЂ‰3В mL/L human erythrocytes) conditions at time points 30 and 60В s. Gargling with antiseptic formulation may have potential role in eliminating the virus in the throat. Due to limited treatment options, preventive measures play major role in controlling the disease spread. Moreover, more than half of the infected patients were young and asymptomatic. The COVID-19 is difficult to contain due to its high transmissibility rate and a long incubation period of 5 to 14В days.

Stop spead swine flu docxtor advice salt swab gargle